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L-779,450
Artikelnummer: Cay17807-1
L-779,450 is an ATP-competitive B-Raf inhibitor (IC50 = 10 nM, Kd = 2.4 nM) that displays >7, >30, and >70-fold selectivity over p38alpha, GSK3beta, and Lck, respectively. It has been shown to inhibit cell proliferation both in B-Raf mutated and wild-type melanoma cell lines, as well as to enhance tumor necrosis...
| Schlagworte: | Raf Kinase Inhibitor IV, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol |
| Anwendung: | Raf kinase inhibitor |
| CAS | 303727-31-3 |
| MW: | 347.8 D |
ab 49,00 €
