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D 4476
Artikelnummer: Cay13305-5
D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1, IC50 = 200 nM from S. pombe, 300 nM for CK1delta). It is a less effective inhibitor of PKD1 (IC50 = 9.1 µM) and p38alpha MAPK (IC50 = 5.8 µM), and only weakly affects the activities of a panel of kinases tested. D 4476 blocks CK1-mediated phosphorylation...
| Schlagworte: | Casein Kinase I Inhibitor, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]-benzamide |
| Anwendung: | CK1 inhibitor |
| CAS | 301836-43-1 |
| MW: | 398.4 D |
ab 40,00 €
NEU
D4476
Artikelnummer: TGM-T2449-100mg
Description: D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay). Target: ALK, Apoptosis, Casein Kinase, Autophagy. Smiles: NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCCOc2c1. References: Rena G, et al. EMBO Rep....
| Schlagworte: | Casein Kinase I Inhibitor, D 4476 |
| CAS | 301836-43-1 |
| MW: | 398.41 D |
ab 44,00 €
