Zu "301836-41-9" wurden 2 Artikel gefunden!
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SB-431542
Artikelnummer: LKT-S0400.1
SB-431542 inhibits activin receptor-like kinases ALK4, ALK5, and ALK7, this inhibition leads to inhibition of activin and TGF- signaling with no downstream effects on ERK, JNK, or MAPK. SB-431542 exhibits anti-angiogenic and anticancer activity. In vitro, SB-431542 inhibits proliferation and motility of glioma...
| Anwendung: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| CAS | 301836-41-9 |
| MW: | 384.39 D |
ab 94,00 €
SB431542, Free Base
Artikelnummer: LC-S-7800_10mg
Soluble in DMSO. SB-431542 selectively inhibited Smad3 phosphorylation, with an IC50 of 94 nM. It also blocked TGF-beta1-induced nuclear Smad3 localization. Laping N.J., et al. 'Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor...
| Schlagworte: | SB 431542, 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate,... |
| Anwendung: | Smad3 phosphorylation inhibitor, TGFBR1/ALK4/ALK7 kinase inhibitor |
| CAS | 301836-41-9 |
| MW: | 384.39 D |
ab 93,00 €
