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UNC8153 (trifluoroacetate salt)
Artikelnummer: Cay38932-1
UNC8153 is a degrader of the histone-lysine N-methyltransferase NSD2. It induces its degradation of NSD2 with a 50% degradation constant (DC50) value of 350 nM and is selective for NSD2 over NSD1 and NSD3 at 20 µM. UNC8153 (10 µM) induces NSD2 degradation and reduces histone H3 lysine 36 dimethylation (H3K36me2) in...
| Schlagworte: | N-[[4-[[[4-[[(6-aminohexyl)amino]carbonyl]phenyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-2H-1,4-benz... |
| Anwendung: | NSD2 degrader |
| CAS | 2929304-61-8 |
| MW: | 697.7 D |
ab 107,00 €
UNC8153 TFA
Artikelnummer: TGM-T83867-10mg
Description: UNC8153 TFA is a selective and potent NSD2 protein degrader with anticancer activity.UNC8153 TFA induces NSD2 degradation in MM.1S multiple myeloma cells and inhibits the proliferation of MM.1S cells. Target: Histone Methyltransferase. Smiles:...
| Anwendung: | NSD2 degrader |
| CAS | 2929304-61-8 |
| MW: | 697.7 D |
ab 62,00 €
