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HS-276
Artikelnummer: Cay43026-10
HS-276 is a TGF-beta-activated kinase 1 (TAK1) inhibitor (IC50 = 8. nM). It is selective for TAK1 over a panel of 137 other kinases at 10 µM but does inhibit CDC-like kinase 2 (Clk2), hexokinase (HK), and unc-51-like autophagy activating kinase 2 (ULK2, IC50s = 29, 33, and 63 nM, respectively). HS-276 inhibits...
| Schlagworte: | N1-[6-(1-piperidinylmethyl)-1-propyl-1H-benzimidazol-2-yl]-1,3-benzenedicarboxamide |
| Anwendung: | TAK1 inhibitor |
| CAS | 2767422-72-8 |
| MW: | 419.53 D |
ab 127,00 €
HS-276
Artikelnummer: TGM-T62209-100mg
Description: HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA). Target: TNF, IRAK, MAPK. Smiles:...
| CAS | 2767422-72-8 |
| MW: | 419.52 D |
ab 60,00 €
