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NEU
(R)-STU104
Artikelnummer: Cay45375-1
(R)-STU104 is an inhibitor of the protein-protein interaction between TGF-beta-activated kinase 1 (TAK1) and MAP kinase kinase 3 (MKK3). It binds MKK3 (KD = 71 nM), inhibits the phosphorylation of MKK3 in RAW 264.7 macrophages (IC50 = 4 µM), and disrupts the interaction between MKK3 and TAK1 in the same cells....
| Schlagworte: | (3R)-2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-1H-inden-1-one |
| Anwendung: | TAK1-MKK3 protein-protein interaction inhibitor |
| CAS | 2767124-77-4 |
| MW: | 298.34 D |
ab 69,00 €
(R)-STU104
Artikelnummer: TGM-T60657-10mg
Description: (R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-alpha and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of MKK3. (R)-STU104 is a candidate compound for the treatment of ulcerative...
| CAS | 2767124-77-4 |
| MW: | 298.33 D |
ab 70,00 €
