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RMC-7977
Artikelnummer: Cay42185-1
A wild-type and mutant Ras protein-protein interaction inhibitor, inhibits the interaction between wild-type K-Ras and seven activating mutation-containing K-Ras variants and C-RAF (EC50s = 5.06-34.5 nM) and the same K-Ras variants and cyclophilin A (EC50s = 1.27-9.12 nM) in BRET assays using U2OS cells expressing...
| Schlagworte: | (1a,5a,6a)-N-[(2R,14S,18S)-2-[5-(4-cyclopropyl-1-piperazinyl)-2-[(1S)- 1-methoxyethyl]-3-pyridinyl]-1-... |
| Anwendung: | Wild-type / mutant Ras protein-protein interaction inhibitor |
| CAS | 2765082-12-8 |
| MW: | 865.1 D |
ab 85,00 €
RMC-7977
Artikelnummer: TGM-T81263-10mg
Description: RMC-7977 is a highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with anticancer activity for the study of solid tumors with KRAS G12C mutations. Target: Raf, Kras, Apoptosis, PARP, AMPK, ERK, Ras, S6 Kinase. Smiles:...
| CAS | 2765082-12-8 |
| MW: | 865.09 D |
ab 242,00 €
