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W1131
Artikelnummer: Cay42902-1
W1131 is a STAT3 inhibitor. It selectively inhibits the phosphorylation of STAT3 over STAT1, STAT5, JAK2, and Akt in AGS gastric adenocarcinoma cells at 3 µM. W1131 binds to STAT3 in a cell-free assay (Kd = 7. µM) and increases the thermal stability of STAT3 in a cellular thermal shift assay (CETSA) using AGS cells...
| Schlagworte: | 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl]-2-furancarboxamide |
| Anwendung: | STAT3 inhibitor |
| CAS | 2740522-79-4 |
| MW: | 429.44 D |
ab 103,00 €
W1131
Artikelnummer: TGM-T73558-100mg
Description: W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PDX). Additionally, W1131 overcomes chemical resistance in cancer cells to 5-FU by...
| CAS | 2740522-79-4 |
| MW: | 429.43 D |
ab 932,00 €
