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Tirapazamine
Artikelnummer: TGM-T4434-100mg
Description: Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin. Target: Others....
| Schlagworte: | SR259075, SR4233, Win59075, Tirazone |
| Anwendung: | Targets DNA topoisomerase II [EC:5.6.2.2] (TOP2) |
| CAS | 27314-97-2 |
| MW: | 178.15 D |
ab 31,00 €
Tirapazamine
Artikelnummer: LKT-T3468.10
Is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia.
| Anwendung: | Antineoplastic |
| CAS | 27314-97-2 |
| MW: | 178,15 D |
ab 126,00 €
Tirapazamine
Artikelnummer: Cay25981-10
Tirapazamine is a hypoxia-activated anticancer agent. It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity. Tirapazamine induces...
| Schlagworte: | 3-Amino-1,2,4-benzotriazine 1,4-Dioxide, SR 259075, SR 4233, WIN 59075, 1,2,4-benzotriazin-3-amine 1,4-dioxide |
| Anwendung: | Antineoplastic, hypoxia-activated anticancer agen |
| CAS | 27314-97-2 |
| MW: | 178.2 D |
ab 85,00 €
