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SKLB197
Artikelnummer: Cay45728-10
SKLB197 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR) (IC50 = 0.013 µM). It is selective for ATR over a panel of 402 other kinases (IC50s = >1 µM). SKLB197 reduces growth in cancer cell lines deficient in ataxia-telangiectasia mutated kinase (ATM, IC50s = 0.13-0.66 µM) to a greater...
| Schlagworte: | 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1methyl-1H-pyrazol-5-yl)-quinazoline |
| Anwendung: | ATR inhibitor |
| CAS | 2713577-16-1 |
| MW: | 424.51 D |
ab 249,00 €
SKLB-197
Artikelnummer: TGM-T62290-100mg
Description: SKLB-197 is able to act on ATR (IC50: 0.013 µM), but has little or no activity on the other 402 protein kinases. In vitro and in vivo, SKLB-197 has shown significant antitumour effects against ATM-deficient tumours. Target: Others. Smiles: C[C@@H]1COCCN1c1nc(nc2ccc(cc12)-c1ccnn1C)-c1cccc2[nH]ccc12
| CAS | 2713577-16-1 |
| MW: | 424.5 D |
ab 676,00 €
