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Glecirasib
Artikelnummer: Cay45041-1
A covalent K-RasG12C inhibitor (IC50 = 1.6 nM), inhibits ERK phosphorylation in K-RasG12C-expressing NCI H358 non-small cell lung cancer (NSCLC) cells (IC50 = 7.3 nM) and reduces their viability (IC50 = 23 nM), inhibits tumor growth in an NCI H1373 NSCLC mouse xenograft model at 10 mg/kg. SMILES:...
| Schlagworte: | 7-(2-amino-3,4,5,6-tetrafluorophenyl)-6-chloro-1,2-dihydro-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-2-oxo-4-[4-(1-oxo-2-... |
| Anwendung: | Covalent K-RasG12C inhibitor |
| CAS | 2657613-87-9 |
| MW: | 640.04 D |
ab 147,00 €
Glecirasib
Artikelnummer: TGM-T78651-25mg
Description: Glecirasib (KRAS G12C inhibitor 36) is a potent inhibitor of the oncogenic KRAS G12C mutation, a critical Ras protein crucial for cell growth and development. This compound shows promise for investigating cancers mediated by KRAS G12C mutations[1]. Target: Ras
| Schlagworte: | JAB-21822, KRAS G12C inhibitor 36 |
| CAS | 2657613-87-9 |
| MW: | 640.03 D |
ab 602,00 €
