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MRTX0902
Artikelnummer: TGM-T9755-100mg
Description: MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM. Target: Raf. Smiles: C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(C#N)c1C. References: Ketcham JM, et al. Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable...
| Schlagworte: | UNII-CRG69FR93G |
| Anwendung: | SOS1-K-Ras(G12C) protein-protein interaction inhibitor |
| CAS | 2654743-22-1 |
| MW: | 388.47 D |
ab 86,00 €
MRTX-0902
Artikelnummer: Cay38578-1
MRTX-0902 is an inhibitor of the protein-protein interaction between son of sevenless homolog 1 (SOS1) and K-Ras containing a glycine-to-cysteine mutation at position 12 (K-RasG12C, Ki = 1.9 nM). It is selective for the SOS1-K-RasG12C protein-protein interaction over the SOS1 and wild-type K-Ras protein-protein...
| Schlagworte: | 2-methyl-3-[(1R)-1-[[4-methyl-7-(4-morpholinyl)pyrido[3,4-d]pyridazin-1-yl]amino]ethyl]-benzonitrile |
| Anwendung: | SOS1-K-Ras(G12C) protein-protein interaction inhibitor |
| CAS | 2654743-22-1 |
| MW: | 388.5 D |
ab 103,00 €
