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ART812
Artikelnummer: Cay42904-1
ART812 is an inhibitor of DNA polymerase theta (IC50 = 7. nM). It inhibits microhomology-mediated end joining (MMEJ) in a reporter assay using HEK293 cells (EC50 = 240 nM). ART812 (150 mg/kg twice per day) increases blood levels of micronucleated reticulocytes in mice. It inhibits tumor development in a Brca1- and...
| Schlagworte: | (2S,3S,4S)-N-(3-chloro-4-fluorophenyl)-3,4-dihydroxy-N-methyl-1-[6-methyl-4-(trifluoromethyl)-2-pyridinyl]-5-oxo-2-pyrroli... |
| Anwendung: | DNA polymerase theta (POLQ) inhibitor |
| CAS | 2607138-82-7 |
| MW: | 461.8 D |
ab 118,00 €
ART812
Artikelnummer: TGM-T40236-100mg
Description: ART812 is an orally active inhibitor of DNA polymerase Poltheta, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM. Target: DNA/RNA Synthesis. Smiles:...
| Schlagworte: | ART812 |
| CAS | 2607138-82-7 |
| MW: | 461.79 D |
ab 111,00 €
