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UNC6934
Artikelnummer: TGM-T9584-1mg
Description: UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. Target: Histone Methyltransferase, HIF/HIF Prolyl-Hydroxylase. Smiles: O=C(Nc1ccncn1)c1ccc(CN(C2CC2)C(=O)c2ccc3NC(=O)COc3c2)cc1. References: Dilworth D, et al. A chemical probe targeting the PWWP domain alters NSD2...
| Anwendung: | NSD2-H3K36me2 nucleosome interaction inhibitor |
| CAS | 2561494-77-5 |
| MW: | 443.45 D |
ab 40,00 €
UNC6934
Artikelnummer: Cay28814-10
UNC6934 is an inhibitor of the protein-protein interaction between histone-lysine N-methyltransferase NSD2 and dimethylated lysine 36 histone 3 (H3K36me2) nucleosomes (IC50 = 104 nM). It binds to NSD2 (Kd = 92 nM). UNC6934 also inhibits the serotonin transporter (SERT) and µ-opioid receptor (Kis = 1.4 and 8 µM,...
| Schlagworte: | N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide |
| Anwendung: | NSD2-H3K36me2 nucleosome interaction inhibitor |
| CAS | 2561494-77-5 |
| MW: | 443.5 D |
ab 91,00 €
