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ARUK3001185
Artikelnummer: TGM-T60537-100mg
Description: ARUK3001185 (Compound 8l) is a potent, selective, orally active, and brain-penetrant Notum inhibitor (IC50 = 6.7 nM), suitable for oral dosing in rodent models of disease [1]. Target: Others. Smiles: C(F)(F)(F)C1=C(Cl)C(=CC=C1Cl)N2C=CN=N2
| Anwendung: | NOTUM inhibitor |
| CAS | 2411969-39-4 |
| MW: | 282.05 D |
ab 94,00 €
ARUK3001185
Artikelnummer: Cay37113-1
ARUK3001185 is an inhibitor of palmitoleoyl-protein carboxylesterase NOTUM (IC50 = 6.7 nM), an enzyme involved in the deacylation of Wnt. It is selective for NOTUM over a panel of 39 serine hydrolases and 485 kinases, including casein kinase 1 (CK1) and glycogen synthase kinase 3 (GSK3), at 10 µM and a panel of 47...
| Schlagworte: | 1-Phenyl-1H-1,2,3-triazole 1, 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazole |
| Anwendung: | NOTUM inhibitor |
| CAS | 2411969-39-4 |
| MW: | 282.1 D |
ab 69,00 €
