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SR-4835
Artikelnummer: TGM-T8325-100mg
Description: SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM, CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells. Target: Apoptosis, CDK. Smiles: Cn1cc(cn1)-n1cnc2c(NCc3nc4cc(Cl)c(Cl)cc4[nH]3)nc(nc12)N1CCOCC1. References: Quereda V, et al....
| Anwendung: | Cdk12 / Cdk13 inhibitor |
| CAS | 2387704-62-1 |
| MW: | 499.36 D |
ab 52,00 €
SR 4835
Artikelnummer: Cay39158-10
SR 4835 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13. It binds to Cdk12 and Cdk13 (Kds = 98 and 4.9 nM, respectively) and inhibits Cdk12- and Cdk13-dependent phosphorylation of RNA polymerase II in MDA-MB-231 cells (EC50 = 105.5 nM). SR 4835 inhibits the proliferation of MDA-MB-231, MDA-MB-468, Hs...
| Schlagworte: | N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methyl-1H-pyrazol-4-yl)-2-(4-morpholinyl)-9H-purin-6-amine |
| Anwendung: | Cdk12 / Cdk13 inhibitor |
| CAS | 2387704-62-1 |
| MW: | 499.4 D |
ab 49,00 €
