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TH9619
Artikelnummer: Cay45380-1
An MTHFD inhibitor (IC50s = 16, 47, and 47 nM, respectively), inhibits nuclear MTHFD2 and cytoplasmic MTHFD1 but not mitochondrial MTHFD2, leading to an increase in 10-CHO-THF, thymidylate depletion, and cell death, selective for MTHFD1 and MTHFD2 over a panel of 44 kinases at 12 µM, reduces proliferation in a panel...
| Schlagworte: | N-[[5-[[2-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamic acid |
| Anwendung: | MTHFD inhibitor |
| CAS | 2379556-22-4 |
| MW: | 451.37 D |
ab 133,00 €
