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HRX215
Artikelnummer: Cay41238-1
HRX215 is an inhibitor of MAP kinase kinase 4 (MKK4, IC50 = 0. µM). It is selective for MKK4 over JNK1, B-RAF, and MKK7 (IC50s = 7. 11. and 14. µM, respectively). HRX215 (10 mg/kg) decreases hepatocyte apoptosis in a mouse model of liver damage induced by carbon tetrachloride (CCl4). It increases survival and...
| Schlagworte: | Darizmetinib, LN3348,... |
| Anwendung: | MKK4 (MAP2K4) inhibitor |
| CAS | 2369583-33-3 |
| MW: | 457.45 D |
ab 186,00 €
Darizmetinib
Artikelnummer: TGM-T72956-25mg
Description: Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Target: Antiviral, MAPK. Smiles:...
| Schlagworte: | HRX215, HRX-0215 |
| CAS | 2369583-33-3 |
| MW: | 457.45 D |
ab 1.222,00 €
