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GSK840
Artikelnummer: Cay35661-1
GSK840 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 0.3 nM). It is selective for RIPK3 over a panel of 300 additional kinases at 1 µM. GSK840 (0.04-1 µM) inhibits TNF-alpha-induced necroptosis in primary human neutrophils isolated from human whole blood. It also inhibits LPS-induced...
| Schlagworte: | 4-[5-[(methylamino)carbonyl]-1H-benzimidazol-1-yl]-benzeneacetic acid, 1,1-dimethylethyl ester |
| Anwendung: | RIPK3 inhibitor |
| CAS | 2361146-30-5 |
| MW: | 365.4 D |
ab 38,00 €
GSK840
Artikelnummer: TGM-T11501-10mg
Description: GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor that binds to the RIP3 kinase domain (IC50: 0.9 nM) and inhibits kinase activity (IC50: 0.3 nM). Target: RIP kinase. Smiles: CNC(=O)c1ccc2n(cnc2c1)-c1ccc(CC(=O)OC(C)(C)C)cc1. References: Mandal P, et al. RIP3 induces...
| Schlagworte: | GSK'840 |
| CAS | 2361146-30-5 |
| MW: | 365.43 D |
ab 31,00 €
