Zu "2359650-19-2" wurden 2 Artikel gefunden!
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TPX-0046
Artikelnummer: TGM-T35384-100mg
Description: TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib. Target: c-RET, Src. Smiles: FC=1C=C2CN3C=4C(=CN5C(N4)=C(C=N5)C(=O)NC[C@@H](C)OC2=NC1)O[C@]6([C@@]3(CCC6)[H])[H]. References: Repetto M, et al. The return of RET GateKeeper mutations? an in-silico exploratory...
| CAS | 2359650-19-2 |
| MW: | 424.43 D |
ab 149,00 €
TPX-0046
Artikelnummer: Cay41990-1
A RET inhibitor (IC50 = 0.26 nM for the wild-type enzyme), selective for RET over a panel of 217 additional kinases but does inhibit 39 tyrosine kinases by > 50% at 26 nM, inhibits the phosphorylation of wild-type RET (IC50 = 21.9 nM) and 15 RET mutants (IC50s = 2.69-108 nM) in Ba/F3 cells. Formulation: A solid....
| Schlagworte: | Enbezotinib,... |
| Anwendung: | RET inhibitor |
| CAS | 2359650-19-2 |
| MW: | 424.4 D |
ab 139,00 €
