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NVP-AEW541 (hydrochloride)
Artikelnummer: Cay13641-1
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50 = 0.15 µM in a cell-free assay). It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2,...
| Schlagworte: | 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, dihydrochloride |
| Anwendung: | IGF-1R kinase inhibitor |
| CAS | 2320261-63-8 |
| MW: | 512.5 D |
ab 122,00 €
AEW541 HCl
Artikelnummer: TGM-T69682-10mg
Description: AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at...
| Anwendung: | IGF-1R kinase inhibitor |
| CAS | 2320261-63-8 |
| MW: | 439.56 D |
ab 271,00 €
