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AMG 510
Artikelnummer: Cay29465-1
AMG 510 is a covalent inhibitor of K-RasG12C. It inhibits EGF-induced phosphorylation of ERK1/2 in MIA PaCa-2 cells (IC50 = 68 nM). AMG 510 reduces the viability of MIA PaCa-2 cells that express K-RasG12C but not K-RasG12S-expressing A549 cells (IC50s = 5 and 36,500 nM, respectively). In vivo, AMG 510 (10, 30, and...
| Schlagworte: | (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1... |
| Anwendung: | K-Ras-G12C covalent inhibitor |
| CAS | 2296729-00-3 |
| MW: | 560.6 D |
ab 40,00 €
Sotorasib
Artikelnummer: TGM-T8684-100mg
Description: Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors. Target: Ras. Smiles:...
| Schlagworte: | AMG-510 |
| Anwendung: | Targets GTPase KRas (KRAS, KRAS2) |
| CAS | 2296729-00-3 |
| MW: | 560.59 D |
ab 30,00 €
Sotorasib
Artikelnummer: BPS-82712-1
Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors1,2.
| Schlagworte: | KRAS G12C inhibitor, Sotorasib, AMG-510, |
| Anwendung: | Ras signaling, cancer therapy target |
| CAS | 2296729-00-3 |
| MW: | 560,59 D |
ab 367,00 €
