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TD-106
Artikelnummer: Cay44836-10
TD-106 is a modulator of cereblon. It binds to cereblon in a cellular thermal shift assay (CETSA) using HEK293 cells. TD-106 (1-1,000 nM) induces degradation of the cereblon targets Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in NCI H929 multiple myeloma cells and is cytotoxic to NCI H929 cells (CC50 = 0....
| Schlagworte: | 3-(5-amino-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2,6-piperidinedione |
| Anwendung: | Cereblon modulator |
| CAS | 2250288-69-6 |
| MW: | 273.25 D |
ab 236,00 €
TD-106
Artikelnummer: TGM-T13104-1mL
Description: TD-106 is a modulator of cereblon (CRBN), and can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation. Target: Others. Smiles: O=C1NC(=O)C(N2N=NC=3C=CC=C(N)C3C2=O)CC1. References: Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med...
| CAS | 2250288-69-6 |
| MW: | 273.25 D |
300,00 €
