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WS-383
Artikelnummer: Cay45391-10
An inhibitor of the protein-protein interaction between DCNL1-UBC12 (IC50 = 11 nM in a cell-free assay), selectively inhibits neddylation of cullin-3 and -1 over other cullin proteins and increases levels of p21, p27, and Nrf2 in MGC803 cells at 10 µM, inhibits LSD1 activity in a cell-free assay (IC50 = 288 nM),...
| Schlagworte: | 5-[[2-[[(4-chlorophenyl)methyl]thio]-5-... |
| Anwendung: | DCNL1-UBC12 protein-protein interaction inhibitor |
| CAS | 2247544-02-9 |
| MW: | 498.5 D |
ab 147,00 €
WS-383
Artikelnummer: TGM-T13349-100mg
Description: WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM). Target: E1/E2/E3 Enzyme. Smiles: Cl.CN(C)CCn1nnnc1Sc1cc(C)nc2nc(SCc3ccc(Cl)cc3)nn12. References: Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based...
| CAS | 2247544-02-9 |
| MW: | 498.46 D |
ab 37,00 €
