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DCZ0415
Artikelnummer: Cay42513-1
DCZ0415 is an inhibitor of thyroid hormone receptor interactor 13 (TRIP13). It binds to TRIP13 (Kd = 2. µM) and reduces non-homologous end joining (NHEJ) repair of DNA in a reporter assay. DCZ0415 (10 and 20 µM) impairs DNA repair in ARP-1 and NCI H929 multiple myeloma cells. It reduces the growth of a variety of...
| Schlagworte: | 4,4a,5,5a,6,6a-hexahydro-2-[4-(4-pyridinylmethyl)phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione |
| Anwendung: | TRIP13 inhibitor |
| CAS | 2242470-43-3 |
| MW: | 356.42 D |
ab 76,00 €
DCZ0415
Artikelnummer: TGM-T10981-100mg
Description: DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit NF-kappaB activity. Target: NF-kappaB, Others, Apoptosis. Smiles:...
| CAS | 2242470-43-3 |
| MW: | 356.42 D |
ab 46,00 €
