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MB710
Artikelnummer: Cay45499-1
A stabilizer of mutant p53, increases the thermal stability and inhibits aggregation of the mutant p53Y220C DNA-binding domain (Kd = 4 µM), selectively inhibits growth of NUGC-3 cells expressing p53Y220C over WI38 cells that do not express the p53Y220C mutant (IC50s = 90 and >120 µM, respectively), selectively...
| Schlagworte: | 2-(diethylamino)-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)-4-benzothiazolecarboxylic acid |
| Anwendung: | Mutant p53 stabilizer |
| CAS | 2230044-57-0 |
| MW: | 457.29 D |
ab 69,00 €
MB710
Artikelnummer: TGM-T9661-25mg
Description: MB710, an aminobenzothiazole derivative, stabilizes the oncogenic p53 mutation Y220C by binding tightly to the Y220C pocket, enhancing the stability of p53-Y220C with a dissociation constant (Kd) of 4.1 µM. This compound exhibits anticancer activity in cell lines harboring the p53-Y220C mutation [1]....
| CAS | 2230044-57-0 |
| MW: | 457.29 D |
ab 1.763,00 €
