Zu "2206736-04-9" wurden 2 Artikel gefunden!
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MRTX-1257
Artikelnummer: Cay33527-5
MRTX-1257 is a covalent inhibitor of K-RasG12C. It inhibits proliferation of NCI H358 cells when used at concentrations ranging from 0.001 to 1 µM.Formal Name:...
| Schlagworte: | (2S)-1-(1-oxo-2-propen-1-yl)-4-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]py... |
| Anwendung: | K-RasG12C covalent inhibitor |
| CAS | 2206736-04-9 |
| MW: | 565.7 D |
ab 85,00 €
MRTX-1257
Artikelnummer: TGM-T16143-1mg
Description: MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD...
| Anwendung: | K-RasG12C covalent inhibitor |
| CAS | 2206736-04-9 |
| MW: | 565.71 D |
ab 55,00 €
