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PROTAC Mcl Degrader-1
Artikelnummer: Cay45150-10
A PROTAC that drives Mcl-1 degradation, induces degradation of Mcl-1 in HeLa cells (DC50 = 0.76 µM), induces selective degradation of Mcl-1 over Bcl-2, Bcl-xL, MDM2, and tubulin in HeLa cells at 10 µM, inhibits growth of H23 cells. SMILES:...
| Schlagworte: | Proteolysis-targeting Chimera Mcl Degrader-1,... |
| Anwendung: | Mcl-1 degradation driving PROTAC |
| CAS | 2163793-38-0 |
| MW: | 909.85 D |
ab 91,00 €
PROTAC Mcl1 degrader-1
Artikelnummer: TGM-T11975-100mg
Description: PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with µM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively...
| CAS | 2163793-38-0 |
| MW: | 909.84 D |
ab 75,00 €
