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BI-1347
Artikelnummer: Cay43667-10
BI-1347 is an inhibitor of Cdk8 and Cdk19 (IC50s = 1. and 1. nM, respectively). It is selective for Cdk8 and Cdk19 over Cdk1, -2, -4, -6, -7, and -9 and a panel of 318 additional kinases at 1 µM. In vivo, BI-1347 (10 mg/kg) reduces tumor volume in an MV4-11 mouse xenograft model. InChI:...
| Schlagworte: | 4-[4-(4-isoquinolinyl)phenyl]-N,N-dimethyl-1H-pyrazole-1-acetamide |
| Anwendung: | Cdk8 / Cdk19 inhibitor |
| CAS | 2163056-91-3 |
| MW: | 356.43 D |
ab 111,00 €
BI-1347
Artikelnummer: TGM-T5405-100mg
Description: BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model. Target: CDK. Smiles: CN(C)C(=O)Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccccc12. References: Harald Engelhardt, et al. New phenylpyrazolylacetamide compounds and derivatives as...
| CAS | 2163056-91-3 |
| MW: | 356.42 D |
ab 33,00 €
