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LOXO-292
Artikelnummer: Cay33515-5
LOXO-292 is an inhibitor of the receptor tyrosine kinase RET. It inhibits the phosphorylation of a KIF5B-RET fusion protein expressed in HEK293 cells (IC50 = 4 nM). LOXO-292 selectively inhibits proliferation of cancer cells containing RET mutations or gene fusions, including RETM918T-containing MZ-CRC-1 medullary...
| Schlagworte: | ARRY-192, Selpercatinib,... |
| Anwendung: | RET kinase inhibitor |
| CAS | 2152628-33-4 |
| MW: | 525.6 D |
ab 57,00 €
Selpercatinib
Artikelnummer: TGM-T8222-100mg
Description: Selpercatinib (LOXO-292) is a tyrosine kinase inhibitor with antineoplastic properties, displaying IC50 values of 14.0 nM for RET (WT), 24.1 nM for RET (V804M), and 530.7 nM for RET (G810R). Target: c-RET. Smiles: COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1. References: Steven W....
| Schlagworte: | LOXO-292 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] (RET) |
| CAS | 2152628-33-4 |
| MW: | 525.6 D |
ab 30,00 €
