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AS2717638
Artikelnummer: TGM-T10381-100mg
Description: AS2717638 is an orally active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50: 38 nM for hLPA5). It also significantly improves PGF2alpha-, PGE2-, and AMPA-induced allodynia. Target: Others. Smiles: COc1cc2c(cn(-c3noc4ccc(C)cc34)c(=O)c2cc1OC)C(=O)N1CCCCC1. References: Murai N, et...
| CAS | 2148339-28-8 |
| MW: | 447.48 D |
ab 53,00 €
AS-2717638
Artikelnummer: Cay37787-1
AS-2717638 is a lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50 = 0.038 µM). It is selective for LPA5 over LPA1, LPA2, and LPA3 (IC50s = >10 µM for all) but also binds to adenosine A1 and µ-opioid receptors at 10 µM. It induces analgesia in a rat model of allodynia induced by LPA or geranylgeranyl...
| Schlagworte: | 6,7-dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2H)-isoquinolinone |
| Anwendung: | LPA5 antagonist |
| CAS | 2148339-28-8 |
| MW: | 447.5 D |
ab 112,00 €
