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MD-224
Artikelnummer: Cay40960-1
A PROTAC that drives MDM2 degradation, induces degradation of MDM2, which increases p53 levels, in RS4,11 cells at 10 nM, inhibits the growth of RS4,11 cells (IC50 = 1.5 nM), induces complete tumor regression and does not affect body weight in an RS4,11 mouse xenograft model at 50 mg/kg every other day for three weeks
| Schlagworte: | (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-[4-[[[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol... |
| Anwendung: | MDM2 degradation driving PROTAC |
| CAS | 2136247-12-4 |
| MW: | 889.8 D |
ab 68,00 €
MD-224
Artikelnummer: TGM-T11980-10mg
Description: MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent. Target: Mdm2, E1/E2/E3 Enzyme, PROTACs. Smiles:...
| CAS | 2136247-12-4 |
| MW: | 889.8 D |
ab 60,00 €
