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Purvalanol A
Artikelnummer: Cay14579-5
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of...
| Schlagworte: | NG 60, (2R)-2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Anwendung: | CDK inhibitor |
| CAS | 212844-53-6 |
| MW: | 388.9 D |
ab 51,00 €
Purvalanol A
Artikelnummer: LKT-P8270.1
Arrests cell cycle progression and induces apoptosis by inhibition of cyclin-dependent kinases. Has shown antiviral and anticancer activity in several studies.
| Anwendung: | Apoptosis inducer |
| CAS | 212844-53-6 |
| MW: | 388,89 D |
ab 211,00 €
Purvalanol A
Artikelnummer: AG-CR1-2903-M001
Off-white powder. Soluble in DMSO (30mg/ml), ethanol (10mg/ml), DMF (50mg/ml), methanol or dichloromethane. Potent, cell permeable cyclin-dependent protein kinase (cdk) inhibitor. Inhibits human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well...
| Schlagworte: | 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG 60 |
| Anwendung: | Potent cell permeable cyclin-dependent protein kinase (CDK) inhibitor |
| CAS | 212844-53-6 |
| MW: | 388,9 D |
ab 44,00 €
Purvalanol A
Artikelnummer: TGM-T2059-100mg
Description: Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively. Target: CDK, Apoptosis, Autophagy. Smiles: CC(C)C(CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1. References: Gray NS, et al. Science. 1998, 281(5376),...
| Schlagworte: | NG-60 |
| CAS | 212844-53-6 |
| MW: | 388.89 D |
ab 32,00 €
