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CI-1040
Artikelnummer: Cay11580-5
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50...
| Schlagworte: | PD 184352, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide |
| CAS | 212631-79-3 |
| MW: | 478.7 D |
ab 122,00 €
PD-184352
Artikelnummer: LKT-P1200.5
MEK1/2 and Raf inhibitor.
| Schlagworte: | CI-1040, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide |
| Anwendung: | MEK inhibitor |
| CAS | 212631-79-3 |
| MW: | 478,66 D |
ab 136,00 €
PD 184,352
Artikelnummer: AG-CR1-0029-M001
MEK (MAPKK) inhibitor, Potent and selective MAPK (ERK kinase 1, MEK1) activation inhibitor (IC50 = 300 nM in vitro, IC50 = 2 nM in vivo), Suppresses activation of MAPK but does not block its activity, Antiproliferative, Causes cell-cycle arrest in G1 phase, Tumor suppressor, Apoptosis inducer.
| Schlagworte: | 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040 |
| Anwendung: | MEK inhibitor |
| CAS | 212631-79-3 |
| MW: | 478,7 D |
ab 22,00 €
