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PD 198306
Artikelnummer: Cay23966-1
PD 198306 is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2, IC50 = 8 nM). It is selective for MEK1/2 over ERK, c-Src, PI3Kgamma, and cyclin-dependent kinases (IC50s = >1 µM). PD 198306 (3-100 µM) reduces ERK1/2 phosphorylation and inhibits growth of HL-60 cells in vitro. In vivo, PD 198306...
| Schlagworte: | N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide |
| Anwendung: | MEK1/2 inhibitor |
| CAS | 212631-61-3 |
| MW: | 476.2 D |
ab 100,00 €
PD 198306
Artikelnummer: TGM-T21980-100mg
Description: PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. Target: MEK. Smiles: N(C1=C(C(NOCC2CC2)=O)C=C(F)C(F)=C1F)C3=C(C)C=C(I)C=C3. References: Benoit Besson, et al. Kinome-Wide RNA...
| CAS | 212631-61-3 |
| MW: | 476.23 D |
ab 55,00 €
