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Pirtobrutinib
Pirtobrutinib

Artikelnummer: TGM-T36287-100mg

Description: Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models....
Anwendung: Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK)
CAS 2101700-15-4
MW: 479.43 D
ab 31,00 €
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Pirtobrutinib
Pirtobrutinib

Artikelnummer: Cay36775-10

Pirtobrutinib is an inhibitor of Bruton's tyrosine kinase (BTK). It inhibits wild-type and mutant BTK (IC50s = 10-100 and C481S, respectively). It is selective for BTK over EGFR (IC50 = 1-10 µM). Pirtobrutinib decreases the number of Ki67-positive cells, a marker of cell proliferation, in MEC-1 chronic lymphocytic...
Schlagworte: LOXO-305, LY3527727,...
Anwendung: BTK inhibitor
CAS 2101700-15-4
MW: 479.4 D
ab 132,00 €
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