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LY411575
Artikelnummer: Cay16162-10
gamma-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell...
| Schlagworte: | N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alphaS-hydr... |
| Anwendung: | gamma-?secretase inhibitor |
| CAS | 209984-57-6 |
| MW: | 479.5 D |
ab 58,00 €
LY-411575
Artikelnummer: TGM-T6063-100mg
Description: LY-411575, a potent gamma-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM. Target: Apoptosis, Gamma-secretase. Smiles: C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O. References:...
| Schlagworte: | LY411575 |
| Anwendung: | gamma-?secretase inhibitor |
| CAS | 209984-57-6 |
| MW: | 479.48 D |
ab 37,00 €
