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VX-745
Artikelnummer: AG-CR1-3754-M001
VX-745 is a potent inhibitor of p38alpha MAPK (IC50=10nM) with 20-fold selectivity over p38beta and 1000-fold selectivity over closely related kinases, ERK1, MK2 and JNK1-3. p38alpha is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases and is widely expressed in...
| Schlagworte: | 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one, Neflamapimod, VX745 |
| Anwendung: | p38 alpha inhibitor |
| CAS | 209410-46-8 |
| MW: | 436.3 D |
ab 22,00 €
Neflamapimod
Artikelnummer: TGM-T6089-100mg
Description: Neflamapimod (VX-745) , a specific and effective inhibitor of p38alpha(IC50=10 nM), is 22-fold greater specificity against p38beta and no inhibition activity to p38gamma. Target: Autophagy, p38 MAPK. Smiles: Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1. References: Decicco C, et al. American...
| Schlagworte: | VX-745 |
| Anwendung: | Targets p38 MAP kinase [EC:2.7.11.24] (P38) |
| CAS | 209410-46-8 |
| MW: | 436.26 D |
ab 41,00 €
