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PARG Inhibitor PDD00017273
Artikelnummer: AG-CR1-3646-M001
White to off-white solid. Soluble in DMSO, methanol or acetonitrile. Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies, Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>,30µ,M)....
| Schlagworte: | PARG Inhibitor Compound 4,... |
| Anwendung: | PARG inhibitor |
| CAS | 1945950-21-9 |
| MW: | 514,6 D |
ab 72,00 €
PDD00017273
Artikelnummer: Cay19511-1
PDD00017273 is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM in an enzyme assay). It maintains persistence of nuclear PAR chains in HeLa cells induced by the DNA damaging agent methylmethanesulfonate (MMS, IC50 = 37 nM). PDD00017273, in combination with MMS, increases nuclear phosphorylated H2AX...
| Schlagworte: | 1-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-d... |
| Anwendung: | PARG inhibitor |
| CAS | 1945950-21-9 |
| MW: | 514.6 D |
ab 67,00 €
PDD00017273
Artikelnummer: TGM-T5700-100mg
Description: PDD00017273 is a radiosensitizing PARG) inhibitor with antitumor or activity for the study of epithelial ovaries. Target: Others. Smiles: Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)s3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1. References: Gravells P, et al. Specific killing of DNA damage-response deficient cells with...
| Anwendung: | PARG inhibitor |
| CAS | 1945950-21-9 |
| MW: | 514.62 D |
ab 71,00 €
