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eCF506
Artikelnummer: TGM-T8499-100mg
Description: eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM). Target: Src. Smiles: COc1cc(ccc1NC(=O)OC(C)(C)C)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12. References: Fraser C, et al. Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell...
| Anwendung: | Src / Fyn / Yes inhibitor |
| CAS | 1914078-41-3 |
| MW: | 510.63 D |
ab 42,00 €
eCF506
Artikelnummer: Cay19959-1
eCF506 is an inhibitor of Src kinases (IC50s = 50 = 479 nM), as well as KIT, mTOR, PDGFRalpha, and RET (IC50s = >100 µM for all). eCF506 completely inhibits phosphorylation of Src and FAK, a downstream Src substrate, in MCF-7 and MDA-MB-231 cells when used at a concentration of 100 nM. It also inhibits proliferation...
| Schlagworte: | N-[4-[4-amino-1-[2-[4-(dimethylamino)-1-piperidinyl]ethyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-carbamic... |
| Anwendung: | Src / Fyn / Yes inhibitor |
| CAS | 1914078-41-3 |
| MW: | 510.6 D |
ab 52,00 €
