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Olutasidenib
Artikelnummer: Cay30370-1
Olutasidenib is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1, IC50s = 0.021 and 0.114 µM for IDH1R132H and IDH1R132C, respectively). It is selective for mutant IDH1 over wild-type IDH1 and mutant IDH2 (IC50s = 22.4, 27.3, and >100 µM for wild-type IDH1, IDH2R172K, and IDH2R140Q, respectively)....
| Schlagworte: | FT-2102, 5-[[(1S)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl]amino]-1,6-dihydro-1-methyl-6-oxo-2-pyridinecarbonitrile |
| Anwendung: | Mutant IDH1 inhibitor |
| CAS | 1887014-12-1 |
| MW: | 354.8 D |
ab 93,00 €
Olutasidenib
Artikelnummer: TGM-T16384-100mg
Description: Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Isocitrate dehydrogenase 1 (IDH1) (IC50: 21.2 nM and 114 nM for IDH1- R132H and IDH1-...
| Schlagworte: | FT-2102 |
| Anwendung: | Targets isocitrate dehydrogenase [EC:1.1.1.42] (IDH1, IDH2, icd) |
| CAS | 1887014-12-1 |
| MW: | 354.79 D |
ab 53,00 €
