Zu "1884220-36-3" wurden 2 Artikel gefunden!
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SBI-0206965
Artikelnummer: Cay18477-5
ULK1 is a serine/threonine kinase that acts upstream of phosphatidylinositol 3-kinase (PI3K) to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation. It is activated by phosphorylation by AMPK and, in turn, phosphorylates and inhibits AMPK. SBI-0206965 is...
| Schlagworte: | 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl-benzamide |
| Anwendung: | ULK1 inhibitor |
| CAS | 1884220-36-3 |
| MW: | 489.3 D |
ab 110,00 €
SBI-0206965
Artikelnummer: TGM-T2128-100mg
Description: SBI-0206965 is a potent, selective, and cell-permeable autophagy kinase ULK1 inhibitor with an IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2. Target: Apoptosis, Autophagy. Smiles: CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br. References: Elokdah H, et al. J Med Chem. 2004, 47(14),...
| Schlagworte: | SBI0206965 |
| CAS | 1884220-36-3 |
| MW: | 489.32 D |
ab 37,00 €
