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MBP146-78
Artikelnummer: TGM-T7321-100mg
Description: MBP146-78 is a potent and selective inhibitor of cGMP-dependent protein kinases (cGMP-dependent protein kinases). Target: Parasite. Smiles: CN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1. References: Nare B , Allocco J J , Liberator P A , et al. Evaluation of a Cyclic GMP-Dependent Protein Kinase...
| CAS | 188343-77-3 |
| MW: | 335.42 D |
ab 62,00 €
MBP146-78
Artikelnummer: Cay41083-1
MBP146-78 is an inhibitor of parasitic cGMP-dependent protein kinases (PKGs, IC50s = 1.9 and 1 nM for the E. tenella and T. gondii enzymes, respectively). It inhibits P. berghei sporozoite development into liver-stage parasites in HepG2 cells in a concentration-dependent manner. MBP146-78 (50 mg/kg) prevents P....
| Schlagworte: | 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-pyridine |
| Anwendung: | Parasitic PKG inhibitor |
| CAS | 188343-77-3 |
| MW: | 335.4 D |
ab 45,00 €
MBP146-78
Artikelnummer: SYN-1227-M001
MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG....
| Schlagworte: | 4-[2-(4-Fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl] pyridine |
| Anwendung: | Eimeria spp. cGMP-dependent protein kinase (PKG) inhibitor |
| CAS | 188343-77-3 |
| MW: | 335.4 D |
ab 108,00 €
BGG463
Artikelnummer: SYN-1226-M100
BGG463 (NVP-BGG463) was generated by a rational 'hybrid design' approach. Like Imatinib, BGG463 disrupts the assembly of the hydrophobic spine, a characteristic feature of the active state of several kinases, thereby locking the kinase in an inactive 'DFG-out' conformation. BGG463 can inhibit c-ABL-T334I, BCR-ABL...
| Schlagworte: | BGG-463 |
| Anwendung: | Kinase active state disruptor |
| CAS | 188343-77-3 |
| MW: | 578.6 D |
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