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3PO
Artikelnummer: Cay19276-5
3PO is a competitive inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 3 (PFKFB3, IC50 = 23 µM) that causes a rapid reduction in fructose-2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion. This is followed by a reduction in the steady-state concentration of ATP and NADH, resulting in...
| Schlagworte: | 3-(3-pyridinyl)-1-(4-pyridinyl)-2E-propen-1-one |
| Anwendung: | PFKFB3 inhibitor |
| CAS | 18550-98-6 |
| MW: | 210.2 D |
ab 56,00 €
3PO
Artikelnummer: TGM-T22223-25mg
Description: 3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 µM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 µM). It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH....
| Anwendung: | PFKFB3 inhibitor |
| CAS | 18550-98-6 |
| MW: | 210.23 D |
ab 49,00 €
