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TH1020
Artikelnummer: TGM-T8727-100mg
Description: TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 µm) and specificity. Target: Antibacterial, TLR. Smiles: C(c1ccccc1)n1c(Sc2ncnc3c4cccnc4sc23)nnc1-c1ccncc1. References: Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as...
| Anwendung: | TLR5-flagellin protein-protein interaction inhibitor |
| CAS | 1841460-82-9 |
| MW: | 453.54 D |
ab 40,00 €
TH1020
Artikelnummer: Cay33553-10
TH1020 is an inhibitor of the protein-protein interaction between toll-like receptor 5 (TLR5) and flagellin. It binds to the TLR5 heterodimer interface to disrupt TLR5-flagellin tetramer formation and inhibits flagellin-induced TLR5 signaling in TLR5-overexpressing HEK cells (IC50 = 0.85 µM). TH1020 (0.37 µM)...
| Schlagworte: | 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine |
| Anwendung: | TLR5-flagellin protein-protein interaction inhibitor |
| CAS | 1841460-82-9 |
| MW: | 453.5 D |
ab 128,00 €
