Zu "1802220-02-5" wurden 2 Artikel gefunden!
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TPX-0005
Artikelnummer: Cay23397-1
TPX-0005 is a multi-kinase inhibitor that inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as C-ros oncogene 1 (ROS1, IC50 = 0.07 nM). It inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively). It...
| Schlagworte: | (7S,13R)-11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4... |
| Anwendung: | ATP-competitive ALK/ROS1/TRK inhibitor |
| CAS | 1802220-02-5 |
| MW: | 355.4 D |
ab 51,00 €
Repotrectinib
Artikelnummer: TGM-T4071-100mg
Description: Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 values of 1.01 nM for WT ALK, 5.3 nM for SRC, 1.08 nM for ALK L1196M, and 1.26 nM for ALK G1202R. Target: ALK, ROS, ROS Kinase, Src, Trk receptor. Smiles: C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23. References: Dayong...
| Schlagworte: | TPX-0005, TPX0005, TPX 0005 |
| Anwendung: | Targets proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1] (ROS1) |
| CAS | 1802220-02-5 |
| MW: | 355.37 D |
ab 43,00 €
