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NCB-0846
Artikelnummer: Cay33268-1
NPC-0846 is an inhibitor of TRAF2- and NCK-interacting kinase (TNIK, IC50 = 21 nM). It is selective for TNIK over a panel of 46 kinases but does inhibit FLT3, JAK3, PDGFRalpha, TrkA, Cdk2/CycA2, and HGK by greater than 80% at 100 nM. NPC-0845 (3 µM) inhibits phosphorylation of transcription factor 4 (TCF4) and...
| Schlagworte: | cis-4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol |
| Anwendung: | TNIK inhibitor |
| CAS | 1792999-26-8 |
| MW: | 375.4 D |
ab 58,00 €
NCB-0846
Artikelnummer: TGM-T4011-100mg
Description: NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM). Target: Wnt/beta-catenin, MAPK. Smiles: O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4nc[nH]c4c3)nc12. References: Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26,7:12586.
| Schlagworte: | NCB 0846 |
| Anwendung: | TNIK inhibitor |
| CAS | 1792999-26-8 |
| MW: | 375.42 D |
ab 30,00 €
