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NVS-PAK1-1
Artikelnummer: TGM-T16367-100mg
Description: NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM). Target: PAK. Smiles: CC(C)NC(=O)N1CC[C@@H](C1)NC1=Nc2cc(F)ccc2N(CC(F)F)c2ccc(Cl)cc12. References: Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem...
| Anwendung: | Allosteric PAK1 inhibitor |
| CAS | 1783816-74-9 |
| MW: | 479.93 D |
ab 45,00 €
NVS-PAK1-1
Artikelnummer: Cay19964-10
NVS-PAK1-1 is an allosteric inhibitor of p21-activated kinase 1 (PAK1), a non-receptor serine/threonine kinase involved in tumorigenesis (Kd = 7 nM). It has an IC50 value of 5.2 nM in a PAK1 dephosphorylation assay. NVS-PAK1-1 is selective for PAK1 over PAK2 (Kd = 400 nM) and over a panel of 442 kinases, where it...
| Schlagworte: | (3S)-3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-1-pyrrolidine... |
| Anwendung: | Allosteric PAK1 inhibitor |
| CAS | 1783816-74-9 |
| MW: | 479.9 D |
ab 166,00 €
