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LY315920
Artikelnummer: Cay18267-5
LY315920 is an inhibitor of human group IIA (hGIIA) secretory phospholipase A2 (sPLA2, IC50 = 9 nM). It also potently inhibits human GIIE and GX isoforms, as well as the corresponding mouse isoforms, but poorly inhibits other PLA2 enzymes. LY315920 inhibits sPLA2-induced release of thromboxane A2 from isolated...
| Schlagworte: | Varespladib, 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-acetic acid |
| Anwendung: | Secretory phospholipase A2 (PLA2) inhibitor |
| CAS | 172732-68-2 |
| MW: | 380.4 D |
ab 128,00 €
Varespladib
Artikelnummer: TGM-T2044-100mg
Description: Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and prevention of sickle cell disease, vaso-occlusive crisis, and acute coronary syndrome. Target: Phospholipase. Smiles:...
| Schlagworte: | LY315920 |
| Anwendung: | Targets platelet-activating factor acetylhydrolase [EC:3.1.1.47] (PLA2G7, PAFAH) |
| CAS | 172732-68-2 |
| MW: | 380.39 D |
ab 37,00 €
