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Enzastaurin
Artikelnummer: Cay11601-5
Enzastaurin is a potent inhibitor of PKCbeta (IC50 = 6 nM), with modest selectivity over PKCalpha, PKCgamma, and PKCepsilon (IC50 = 39, 83, and 110 nM, respectively). At 3 µM, enzastaurin also inhibits signaling through the Akt pathway. It suppresses angiogenesis, induces apoptosis, and reduces proliferation of...
| Schlagworte: | LY317615, 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione |
| Anwendung: | PKCbeta inhibitor |
| CAS | 170364-57-5 |
| MW: | 515.6 D |
ab 128,00 €
Enzastaurin, Free Base
Artikelnummer: E3317-75.10
Enzastaurin inhibits PKCb, PKCa, PKCy and PKCe with IC50's of 0.006, 0.039, 0.083 and 0.110uM, respectively. Enzastaurin apparently inhibits tumor growth via multiple mechanisms: suppression of tumor cell proliferation, induction of tumor cell apoptosis and inhibition of tumor-induced angiogenesis. Solubility:...
| CAS | 170364-57-5 |
| MW: | 515.60 |
260,00 €
Enzastaurin
Artikelnummer: TGM-T6280-100mg
Description: Enzastaurin (LY317615) (LY317615) is an effective PKCbeta selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCalpha/gamma/epsilon. Target: Apoptosis, Autophagy, PKC. Smiles: O=C1C(C=2C=3C(N(C2)C4CCN(CC5=CC=CC=N5)CC4)=CC=CC3)=C(C(=O)N1)C=6C=7C(N(C)C6)=CC=CC7. References: Graff JR, et...
| Schlagworte: | LY317615 |
| Anwendung: | Targets classical protein kinase C beta type [EC:2.7.11.13] (PRKCB) |
| CAS | 170364-57-5 |
| MW: | 515.6 D |
ab 41,00 €
